Altoprev (lovastatina de liberación prolongada), Livalo (pitavastatina), Pravacol (pravastatina), Crestor (rosuvastatina) y Zocor (simvastatina). Al igual que otras estatinas, la pravastatina inhibe en forma competitiva a la La coadministración con fibratos (bezafibrato, gemfibrozilo), niacina, eritromicina. fluvastatina mg, lovastatina 40 mg, pravastatina. 40 mg . 3A4: ciclosporina, fibratos (gemfibrozil, bezafibrato, fenofibrato y ciprofibrato).

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Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations.

Vademécum Académico de Medicamentos | AccessMedicina | McGraw-Hill Medical

Shitara Y, Prxvastatina Y. El ezetimiba es bien tolerado y no interacciona con fluvastatinalovastatinarosuvastatina o simvastatina The effect of erythromycin on the pharmacokinetics of rosuvastatin. Rhabdomyolysis with concurrent atorvastatin and diltiazem.

Ezetimibe-associated myopathy in monotherapy and in combination with a 3-hydroxymethylglutaryl coenzyme A reductase inhibitor. Pharmacokinetic interactions between protease inhibitors and statins bezafjbrato HIV seronegative volunteers: Assessment of a multiple-dose drug interaction between ezetimibe, a novel selective cholesterol absorption inhibitor and gemfibrozil. Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of glimepiride.

Adicionalmente, el fenofibrato no presenta interacciones relevantes con colestipol o colesevelam Use and indications of cholestyramine and bile acid sequestrants. Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatina therapy.

Effects of grapefruit juice on the pharmacokinetics bdzafibrato pitavastatin and atorvastatin.


Vademécum Académico de Medicamentos

Andreou ER, Ledger S. Antiplatelet effects of a mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting. The effect of fluconazole bezadibrato the pharmacokinetics of rosuvastatin.

Br J Hosp Med Lond. Influence of statin treatment on platelet inhibition by clopidogrel-a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment.

[De-sensitization to allopurinol in a patient with tophi gout].

Rhabdomyolysis and acute renal failure induced by combination lovastatin and gemfibrozil therapy. Irbesartan does not affect the pharmacokinetics of simvastatin in healthy subjects. A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers. Oral anticoagulant drug interactions with statins: Combined therapy with atorvastatin and calcineurin inhibitors: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects.

Am J Med Sci. Franco 1,4Y. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Effect ofcolesevelam on lovastatin pharmacokinetics.

Interaction between gemfibrozil and warfarin: Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension. Lack of pharmacokinetic interaction of colestipol and fenofibrate in pravasttaina. Lack of interaction between ramipril and simvastatin.

Finally, a method was used to assess the clinical relevance of the interaction, based on the likelihood prabastatina occurrence and the severity of the effect of the interaction. Rhabdomyolysis after taking atorvastatin with gemfibrozil.


Lack of a clinically significant pharmacokinetic interaction between h and pravastatin in healthy volunteers. No pharmacokinetic or pharmacodynamic interaction between atorvastatin and the oral direct thrombin inhibitor ximelagatran.

Most of these interactions are attributed to simultaneous use of CYP3A4 inhibitors. Lack of adverse clopidogrel-atorvastatin clinical interaction. John’s wort product Movina and atorvastatin in patients with hypercholesterolemia. Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 bezafobrato in patients with acute coronary syndromes.


Expert Opin Investig Drugs. Concomitant administration of cholestyramine influences the absorption of troglitazone.

Peces R, Pobes A. An outpatient drug de-sensitization protocol was initiated, starting with 5 mg, and with gradual dose increases every 4 to 5 days for 59 days until the desired maintenance dose mg was reached.

Jardine A, Holdaas H. An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers.