Interpolymer interactions between the countercharged polymers like Eudragit® EPO (polycation) and hypromellose acetate succinate. PDF | The objective of this investigation was to evaluate the potential of Eudragit EPO nanoparticles (EPO NP) in improving therapeutic efficacy. Download scientific diagram | Molecular structures of (a) MFA, (b) EUDRAGIT® EPO, and (c) EUDRAGIT® L from publication: Stabilization of a.

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Evonik EUDRAGIT® E PO Copolymer

This is due to the high degree of interaction that could exist eudragkt both polymers were ionized and maximum level charge density was obtained especially in acidic and buffer media. Various types of oppositely charged polyelectrolytes interact electrostatically in aqueous media to form an insoluble solid or PEC 2 — 5.

Tablet thickness of the matrix tablets was examined for six tablets of each batch using an electronic digital caliper. FT-IR spectrum of pure polymers. Polymethacrylate polymers have been widely used in pharmaceutical formulations as film-coating agent and as matrix carriers in solid dispersion preparation and in hot-melt extrusion processes 13 — As may be appreciated, the latter is different from the rest of the spectra.

To confirm the diffusion mechanism, the data was further fitted into Korsmeyer-Peppas equation Floating and sustained-release characteristics of effervescent tablets prepared with a mixed matrix eo Eudragit L and Eudragit E PO.

The release rate was slowest for the higher polymer concentration formulation F8 with a K value of 7. The contents, results, and technical data from this site may not be reproduced either electronically, photographically or substantively without permission from MatWeb, LLC.


Increasing the total amount of polymers in the formulation from mg F10 to mg F9 ejdragit mg F8 resulted in a slower release rate and extended drug release from the tablet.

The authors are grateful to Mylan laboratories Limited, Hyderabad, India, for the generous gift samples of acetaminophen and excipients. J Appl Polym Sci.

Amoxicillin loaded chitosan-alginate polyelectrolyte complex nanoparticles as eydragit delivery system for h. Please read our License Agreement regarding materials data and our Privacy Policy.

The drug release from the matrix tablets containing a single polymer as matrix former in 0. It can be seen from Fig. The thickness of the tablets varied depending on bulk density of the dried granules used and the compression force applied.

Kinetic Analysis of Release Data To describe the kinetics of drug release from the selected matrix formulation F8release data was analyzed according to different kinetic equations.

Mechanism of solute release from porous hydrophilic polymers. Chemical structure of a EL and b EE polymer. Tablets with mg of the polymers were compacted manually from the physical mixtures using a 9-mm punch in a tablet compression machine. We also ask that you refer to MatWeb’s terms of use regarding this information. The eudragi mixture of polymer mixtures showed the bands for the single components data not shown. The matrix tablets of selected formulations were weighed and placed in tared metallic baskets.

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These profiles could be controlled by conveniently modifying the proportion of uedragit polymer ratio, polymer type, and polymer concentration the in the tablets. Ho C, Hwang GC. To study the effect of anionic and cationic polymer ratio and polymer concentration on the release profile of the drug from the matrix system. Enteric microsphere formulations of papain for oral delivery. Where n is the number of pull points, R t is the reference profile at time point tand T t eudragih the test profile at the same time point; the value of f 2 should be between 50 and Received Aug 4; Accepted Nov MDT was calculated from dissolution data using Eq.


FT-IR spectrum of treated polymers. To ep the effect of enteric polymer type on the release profile of the drug from the matrix system. As an alternative for this lengthy process, we propose in situ EE-enteric polymer polyelectrolyte complexation in an acidic medium simulating the gastric fluid. Case II transport or relaxation controlled delivery; the exponent n is 0.

The formation of inter-macromolecular ionic bonds between cationic polymer and anionic polymer was investigated using Fourier transform infrared FT-IR spectroscopy and differential scanning calorimetry. Dissolution of tablets prepared using different polymer eudrafit in pH 6. Subscribe to Premium Services Searches: Combination of anionic polymers EL and cationic polymers EE for possible sustained release drug delivery has been reported in the eudrait Several different types of eudragut phthalate HP50, HP55, HP55S are commercially available with molecular weights in the range 20,—, The selection of anionic and cationic polymers forming the PEC can be made on the basis of their physicochemical properties such as biocompatibility, physicochemical stability, pH-dependent solubility, and swellability characteristics, etc.