Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.

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Quantitative spectrophotometric estimation of cefadroxil using hydrotropic solubilization yhdrotropic. The solubility study was carried out in triplicate and observations were shown in Table 6.

Hydrotrope – Wikipedia

Standard stock solution of Lumefantrine was prepared by dissolving mg of drug in ml of 0. Here, Lumafantrine was selected as model drug. Same operation was repeated till some excess drug remained undissolved after constant vigorous shaking for 10 minutes. Intermediate precision study expresses variation within laboratory conditions in different days.

Accuracy and reproducibility of the proposed method were further confirmed by recovery studies. There was more than a 18? By this Study we can solubilizafion that, Solubility is the most important physical bydrotropic of a drug for its oral bioavailability, formulation, development of different dosage form of different drugs and for quantitative analysis.

Solubility is one of the important parameter to achieve desired sopubilization of drug in systemic circulation for pharmacological response to be shown[2].

Investigations on the mechanism of aqueous solubility increase caused by some hydrotropes, Thermochimica Acta. Various techniques have been employed to enhance the aqueous solubility of poorly water-soluble drugs. The authors are thankful for Gokula Education Foundation for providing necessary facilities to carry out the research work.

Journal of Pharmacy Research ; 3 3: Solubility can be enhanced by many techniques among them hydrotropy is of very much importance. Therefore, highly concentrated solutions of hydrotropic agents were used in the present investigation.


Examples of hydrotropes include ureatosylatecumenesulfonate and xylenesulfonate.


Solubility enhancement ratio is another parameter that determines the extent to which the drug is soluble in a particular solvent compared to that of water. When the determined solubility enhancement ratio was at least 5, such hydrotropic solution was selected for that drug.

There was more than 15 fold enhancement in aqueous solubility of benzoic acid in 1. Indian journal pharmaceutical science ; 70 6: Lumefantrine was found to be more soluble at lower pH indicating basic nature of drug. Archived from the original PDF on As a result, daily dose, frequency of administration as well other side effects solubilzation to Lumefantrine would be minimized to a great extent. Hydrochlorothiazide shows maximum absorbance at nm.

However, many hydrotropes do not seem to self-aggregate at all, unless a solubilisate has been added.

Here, diamond is the preferred choice for most applications because of its robustness and durability. Solubility Enhancement Ratio Determination: Because of their low aqueous solubility and high permeability, dissolution from delivery systems forms the rate limiting step in their absorption and systemic bioavailability [ 2hydrorropic ].

SD was evaluated for dissolution rate and a marked increase in dissolution rate was observed with SD. Can’t read the image?

Lornoxicam was a generous gift sample from Life Care Formulations Pvt. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization.


World Journal of Pharmaceutical Research ; 5 8 International Journal of Pharmacy and Pharmaceutical Sciences ; 2 1: Solubility of Lumefantrine in various hydrotropes was also represented in graphical form in Fig. Enhancedchartreusin solubility by hydroxybenzoatehydrotropy.

Solute consists of alkali metal salts hydrotdopic various organic acids. Hydrotropes are in use industrially and commercially in cleaning and personal care product formulations to allow more concentrated formulations of surfactants.


Hydrotropy hydrotopic suggested to be superior to other solubilization method, such as miscibility, micellar solubilization, co solvency and salting in, because the solvent character is independent of pH, has high selectivity and does not require emulsification.

Hence this method was optimized and employed in the analysis of the tablet formulation. Quantitative analysis of theophylline bulk sample using sodium salicylate hydrotrope. Integrated Environmental Assessment and Management. How to cite this article: Aliquots of filtrate obtained were diluted with suitable quantity of required solvent and analyzed solubjlization UV spectrophotometer at nm. LOD hydfotropic LOQ were calculated as andrespectively, where is the slope of the calibration curve and is the standard deviation of response [ 10 ].

Hydrotropes such as sodium benzoate, sodium salicylate, niacinamide, sodium hydroxide, sodium citrate, PEGpolyvinyl alcohol, and urea have been employed to enhance the aqueous solubility of poorly water-soluble drugs [ 3 ].

This hydrotropic phenomenon was employed to prepare solid dispersion SD and syrup of paracetamol. It can be concluded that the concept of hydrotropic solubilization technique is novel, safe, eco-friendly and economic for enhancing bioavailability of poorly water-soluble drugs. It is new, simple, cost-effective, safe, accurate, precise and environmental friendly method for the analysis titrimetric and spectrophotometric of poorly water-soluble drugs titrimetric and spectrophotometric hydrotropicc the use of organic solvents.

Therapeutic response of drug as well bioavailability can be limited by poor aqueous solubility of drugs.